At BioCer Entwicklungs-GmbH our interdisciplinary team combines its broad knowledge and experience to build up innovative ideas for medical technologies. Therefore, we cooperate with renowned scientists and physicians to create and realize new concepts for specific modifications of implant surfaces with sophisticated ceramic coatings.
By applying coatings with a thickness of only a few nanometers we generate biocompatible, anti-allergic, osteoconductive or antibacterial properties or even combinations thereof. The concepts offer new opportunities for therapies and improve the safety for patients and surgeons.
Of course we develop and produce - also as contract manufacturer - strictly according to the guidelines DIN EN ISO 13485 and 93/42 EWG, respectively.
Use our developments for your own product innovation!
The coatings are based on the principle of the sol-gel-technique. A cost-efficient dip- or spray-coating process is carried out via a solution of organic solvents and organometallic compounds. During subsequent drying, a polymer-like layer is formed on the material. This layer is converted by thermal treatment into a ceramic layer. The functional modification is obtained by the coating material itself or the homogeneous incorporation of active fillers into the coating solution.
A. Mauerer, B. Lange, GH Welsch, F. Heidenau, W. Adler, R. Forst, RH, Release of Cu2+ from a copper-filled TiO2 coating in a rabbit model for total knee arthroplasty, J Mater Sci Mater Med. 25 (2014) 813-821
R. Tsaryk, K. Peters, RE Unger, M. Feldmann, B. Hoffmann, F. Heidenau, CJ. Kirkpatrick, Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells, J R Soc Interface. 86 (2013) 20130428
M. Haenle, A. Fritsche, C. Zietz, R. Bader, F. Heidenau, W. Mittelmeier, H. Gollwitzer, An extended spectrum bactericidal titanium dioxide (TiO2 ) coating for metallic implants: in vitro effectiveness against 5 MRSA and mechanical properties, J Mater Sci Mater Med. 22 (2011) 381-387
Andreas Fritsche, Frank Heidenau, Hans-Georg Neumann, Wolfram Mittelmeier and Rainer Bader, Mechanical Properties of Anti-Infectious, Bio-Active and Wear Resistant Ceramic Implant Surface Coatings, Key Engineering Materials 396-398 (2009) 357-360.
S. Winter, D. Velten, F. Aubertin, B. Hoffmann, F. Heidenau, G. Ziegler, Sol-Gel coatings, Interface Influence of Materials and Surface Modifications, In: J. Breme, J. C. Kirkpatrick, R. Thull: Metallic Biomaterial Interfaces, Wiley, Weinheim, 2007, 51-64.
F. Heidenau, W. Mittelmeier, R. Detsch, M. Haenle, F. Stenzel, G. Ziegler, H. Gollwitzer, A novel antibacterial titania coating: Metal ion toxicity and in vitro surface colonization, J. Mater. Sci.: Mater. Med. 16 (2005) 883-888.